5.6.3-A 
VEHICLE CONTROL PERIOD 1 
Necessary only if 
baseline period >1 
week before day 1 
Administer vehicle 2,3 
Left nostril (0.2 ml) 
Left bronchi (20 ml) 
Sample epithelium 
Left and right nostril 
Left and right bronchi 
Safety and efficacy parameters 4 
General assessment ! . . 
Dyspnea index 
General blood 
CBC, ESR 
Clotting 
Chemistry 
Other 
General immunity 
Culture 
Urine 
Routine 
Culture 
24 hr 
EKG 
Roentgenographic 
Chest X-ray 
Chest CT 
Scintigraphic 
Lung function 
Spirometry 
He dilution, DLCO 
Body box 
ABG 
Sputum 
Volume 
Culture 
Bronchoalveolar lavage 
Nasal brush 
Bronchial brush 
Potential difference 
Vector-related 
Anti-Ad antibodies 
Adenovirus culture 
Adenovirus DNA 
Recombinant DNA Research, Volume 16 
[753] 
1 U ID !' eLO . ou ou 
