5.6.4-A 
AdCFTR EXPERIMENTAL TREATMENT PERIOD 1 ' 2 
Necessary only if 
vehicle control period 
>1 week before day 1 
Administer AdCFTR 3 
Left nostril (0.2 ml) 
Left bronchi (20 ml) 
Sample epithelium 
Left and right nostril 
Left and right bronchi 
Safety and efficacy parameters 4 
General assessment 
Dyspnea index 
General blood 
CBC, ESR 5 . 
Clotting 
Chemistry 
Other 
General immunity 
Culture 
Urine 
Routine 
Culture 
24 hr 
EKG 
Roentgenographic 
Chest X-ray 
Chest CT 
Scintigraphic 
Lung function 
Spirometry 
He dilution, DLCO 
Body box 
ABG 
Sputum 
Volume 
Culture 
Bronchoalveolar lavage 
Nasal brush 
Bronchial brush 
Potential difference 
Vector-related 
Anti-Ad antibodies 
Adenovirus culture 
Adenovirus DNA 
Serum TNF 
HIV 
10 
,n, 
□ 
Minii 
sami 
□ 
□ 
10 
[756] 
Months 6 Years 6 I 
irs 
Recombinant DNA Research, Volume 16 
