5.6.3-A 
VEHICLE CONTROL PERIOD 1 
Necessary only if 
baseline period >1 
week before day 1 
Administer vehicle 2,3 
Left nostril (0.2 ml) 
Left bronchi (20 ml) 
Sample epithelium 
Left and right nostril 
Left and right bronchi 
Safety and efficacy parameters 4 
Genera! assessment 
Dyspnea index 
General blood 
CBC, ESR 
Clotting 
Chemistry 
Other 
General immunity 
Culture 
Urine 
Routine 
Culture 
24 hr 
EKG 
Roentgenographic 
Chest X-ray 
Chest CT 
Scintigraphic 
Lung function 
Spirometry 
He dilution, DLCO . . 
Body box 
ABG 
Sputum 
Volume 
Culture 
Bronchoalveolar lavage 
Nasal brush 
Bronchial brush 
Potential difference . . . 
Vector-related 
Anti-Ad antibodies . . 
Adenovirus culture. . 
Recombinant DNA Research, Volume 16 
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: r n^ 
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n c-r in Fir- ?n ppr ; no 1 rr 
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