5.6.4-A 
AdCFTR EXPERIMENTAL TREATMENT PERIOD 1 ' 2 
Necessary only if 
vehicle control period 
>1 week before day 1 
Days 
Months 6 
Years 6 
Administer AdCFTR 3 
Left nostril (0.2 ml) 
Left bronchi (20 ml) 
Sample epithelium 
Left and right nostril 
Left and right bronchi 
Safety and efficacy parameters 4 
General assessment 
Dyspnea index 
General blood 
CBC, ESR 5 . 
Clotting 
Chemistry 
Other 
General immunity 
Culture 
Urine 
Routine 
Culture 
24 hr . . 
EKG 
Roentgenographic 
Chest X-ray 
Chest CT 
Scintigraphic 
Lung function 
Spirometry 
He dilution, DLCO . . 
Body box 
ABG 
Sputum 
Volume 
Culture 
Bronchoalveolar lavage. 
Nasal brush 
Bronchial brush 
Potential difference 
Vector-related 
Anti-Ad antibodies . . 
Adenovirus culture. . 
Adenovirus DNA . . . 
Serum TNF 
pill 
hm 
i£i m 
r&tiz 5 
. B 
Mi 
HIV. 
Recombinant DNA Research, Volume 16 
'Mkl 
0 §5 i 10 |y,5j 20 gj253 30 |35| 40 ' 45 j 50 | 55 60 3-12 
1,1 " M 
18-24 : >3 
Days 
Months Years 
