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Principal Investigator/Program Director (Last, first, middle): Cry S ta 1 
Ronald G. 
BIOGRAPHICAL SKETCH 
Give the following information for the key personnel and consultants and collaborators. Begin will) the principal 
investigator/program director. Photocopy this page for each person. 
JAME 
POSITION TITLE 
Ronald G. Crystal 
Chief, Pulmonary Branch, National Heart, Lung, 
and Blood Institute/NIH 
EDUCATION (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) 
INSTITUTION AND LOCATION 
DEGREE 
YEAR 
CONFERRED 
FIELD OF STUDY 
Tufts University, Medford, Massachusetts 
B . A. 
1962 
Phys ics 
University of Pennsylvania, Philadelphia , PA 
M.S. 
1963 
Phys ics 
University of Pennsylvania, Philadelphia, PA 
M.D. 
1968 
Medic ine 
RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment, experience, and 
honors. Key personnel include the principal investigator and any other individuals who participate in the scientific development or execution of the project 
Key personnel typically will include all individuals with doctoral or other professional degrees, but in some projects will include individuals at the masters or 
baccalaureate level provided they contribute in a substantive way to the scientific development or execution of the project. Include present membership on 
any Federal Government public advisory committee. List, in chronological order, the titles, all authors, and complete references to all publications during the 
past three years and to representative earlier publications pertinent to this application. DO NOT EXCEED TWO PAGES. 
Employment 
1968 - 
1970 
Intern and Assistant Resident in Medicine, Massachusetts 
General Hospital, Boston, Massachusetts 
1970 - 
1972 
Research Associate, Section on Molecular Hematology, 
National Heart and Lung Institute, NIH , Bethesda, MD 
1972 - 
1975 
Head, Section on Pulmonary Biochemistry, National 
Heart and Lung Institute, NIH, Bethesda, MD 
1973 
Clinical Fellow in Chest Medicine, University of 
California, San Francisco, CA 
1975 - 
Present 
Chief, Pulmonary Branch, National Heart, Lung, and 
Blood Institute, NIH, Bethesda, MD 
Military 
1970 - 
1974 
Surgeon, Commissioned Corps, USPHS 
1974 - 
1979 
Senior Surgeon, Commissioned Corps, USPHS 
1979 - 
Present 
Medical Director, Commissioned Corps, USPHS 
Board Certification 
1969 
Diplomat of the National Board of Medical Examiners 
1974 
Diplomat of the American Board of Internal Medicine 
1974 
Diplomat in Pulmonary Disease, American Board of Internal 
Medicine 
Honors (selected) 
Elected member 
Alpha Omega Alpha, American Society for Clinical 
Investigation, Association of American Physicians 
1983 
Public Health Service Commendation medal 
1988 
Public Health Service Outstanding Service medal 
1991 
Public Health Service Meritorious Service Award 
1988 - 
Present 
Chairman, National Heart, Lung, and Blood Institute 
Steering Committee for Alpha 1 - Antitryps in Deficiency 
Nationwide Registry 
1991 - 
1992 
American Thoracic Society Board of Directors 
Publications (Selected from a list of 378) 
Garver RI , Chytil A, Courtney M, Crystal RG . Clonal gene therapy: transplanted mouse 
fibroblast clones express human al-antitrypsin gene in vivo. Science 1987, 237. 
762-764. 
Yoshimura K, Nakamura H, Trapnell BC , Dalemans W, Pavirani A, Lecocq J-P, Crystal 
RG. The cystic fibrosis gene has a "housekeeping" type promoter and is expressed 
at low levels in cells of epithelial origin. J Biol Chem 1991; 266(14): 9140-9144. 
Recombinant DNA Research, Volume 16 
[805] 
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