M.J. Welsh and A.E. Smith, RAC Application 
APPLICATION TO 
NATIONAL INSTITUTES OF HEALTH 
RECOMBINANT DNA ADVISORY COMMITTEE 
TITLE 
CYSTIC FIBROSIS GENE THERAPY USING AN ADENOVIRUS 
VECTOR: IN VIVO SAFETY AND EFFICACY IN NASAL EPITHELIUM 
INVESTIGATORS: 
Michael J. Welsh, M.D. 
Howard Hughes Medical Institute 
Departments of Internal Medicine and Physiology and Biophysics 
University of Iowa College of Medicine 
Iowa City, Iowa 52242 
Alan E. Smith, Ph.D. 
Genzyme Corporation 
One Mountain Road 
Framingham, Massachusetts 01701 
COTNVESTIGATORS. 
UNTV. OF IOWA: 
Joseph Zabner, M.D. 
Department of Internal Medicine 
Devra P. Rich, Ph.D. 
Howard Hughes Medical Institute 
Scott M. Graham, M.D. 
Department of Otolaryngology 
COTNVESTIGATORS. 
GENZYME CORP.: 
Richard J. Gregory, Ph.D. 
Molecular Biology 
Bruce M. Pratt, Ph.D. 
Cell Physiology 
Richard A. Moscicki, M.D. 
Medical Affairs 
Recombinant DNA Research, Volume 16 
[853] 
