PROPOSED RULES 
60131 
Coxsackie A and B viruses 
Cytomegalovi ruses 
Echoviruses-a.il types 
Encephalomyocarditis virus (EMC) 
Flanders virus 
Hart Park virus 
Hepatitis-associated antigen material 
Herpes Diruses— except Herpesinrus simiae 
(Monkey B virus) which is in Class 4 
Corona viruses 
Influenza Diruses— all types except A/PR8/ 
34. which is in Class 1 
Langat virus 
Lymphogranuloma venereum agent 
Measles virus 
Mumps virus 
Parainfluenza virus— all types except Par- 
ainfluenza virus 3, SF4 strain, which is In 
Class 1 
Polioviruses— all types, wild and attenuated 
Poxvi ruses— all types except Alastrim, 
Smallpox. Monkey pox. and Whitepox. 
which depending on experiments, are in 
Class 3 or Class 4 
Bathes virus— all strains except Rabies 
street rims, which should be classified in 
Class 3 when Inoculated into carnivores 
Reovi ruses— all types 
Respiratory syncytial virus 
Rhinoviruses—all types 
Rubella virus 
Simian viruses— all types except Herpes- 
virus simiae ( Monkey B nirus) and Mar- 
burg Dirua, which are in Class 4 
Sindbis virus 
Tens aw virus 
Turlock virus 
Vaccinia virus 
Varicella virus 
Vole rickettsia 
Yellow fever virus. 17D vaccine strain 
C. Class 3 Agents 
1. Bacterial Agents 
Actinobacillus mallei ' 
Bartonella— all species 
Brucella— all species 
Francisella tularensis 
Mycobacterium avium. M. bovts. M. tubercu- 
losis 
Pasteurella multocide type B ("buffalo" and 
other foreign virulent strains *> 
Pseudomonas pseudomallei 1 
Yersenia pestis 
2. Fungal Agents 
Coccidioides immitis 
Histoplasma capsulatum 
Histoplasma capsulatum var. duboisii 
3. Parasitic Agents 
Schistosoma mansoni 
4. Viral, Rickettsial, and Chlamydial Agents 
Alastrim, Smallpox, Monkey pox. and While- 
pox, when used in vitro 
Arboviruses— all strains except those in 
Class 2 and 4 (Arbor! ruses indigenous to 
the United States are in Class 3. except 
those listed in Class 2. West Nile and Sem- 
liki Forest viruses may be classified up or 
down, depending on the conditions of use 
and geographical location of the labora- 
tory.) 
’USDA permit also required for import or 
interstate transport. 
Dengue virus, when used for transmission or 
animal inoculation experiments 
Lymphocytic choriOfneningitis virus (LCM) 
Psittacosis-Omithosis-Trachoma group of 
agents 
Rabies street virus, when used In inocula- 
tions of carnivores (See Class 2) 
Rickettsia— all species except Vole rickettsia 
when used for transmission or animal in- 
oculation experiments 
Vesicular stomatitis virus ’ 
Yellow fever trims— wild, when used in vitro 
D. Class 4 Agents 
1. Bacterial Agents 
None 
2. Fungal Agents 
None 
3. Parasitic Agents 
None 
4. Viral. Rickettsial, and Chlamydial Agents 
Alastrim. Smallpox. Monkey pox. and White- 
pox, when used tor transmission or animal 
inoculation experiments 
Hemorrhagic fever agents Including Cri- 
mean hemorrhagic fever i Congo), Junin, 
and Machupo viruses, and others as yet 
undefined 
Herpesvirus simiae (Monkey B virus) 
Lassa virus 
Marburg vims 
Tick-borne encephalitis vims complex in- 
cluding Russian spring-summer encephali- 
tis. Kyasanur forest disease. Omsk hemorr- 
hagic fever, and Central European en- 
cephalitis viruses 
Venezuelan equine encephalitis vims, epi- 
demic strains, when used tor transmission 
or animal inoculation experiments 
Yellow fever trims— wild, when used for 
transmission or animal inoculation experi- 
ments 
II. Classification of Oncogenic Viruses on 
the Basts of Potential Hazard (2) 
A. Low- Risk Oncogenic Viruses 
Rous Sarcoma 
SV-40 
CELO 
Ad7-SV40 
Polyoma 
Bovine papilloma 
Rat mammary tumor 
Avian Leukosis 
Murine Leukemia 
Murine Sarcoma 
Mouse mammary 
tumor 
Rat Leukemia 
Hamster Leukemia 
Bovine Leukemia 
Dog Sarcoma 
MasonPflzer 
Monkey Virus 
Marek's 
Guinea Pig Herpes 
Lucks (Prog) 
Adenovirus 
Shope Fibroma 
Shope Papilloma 
B. Moderate-Risk Oncogenic Viruses 
Ad2-SV40 
FeLV 
HV Salmirl 
EBV 
8SV-1 
GaLV 
HV ateles 
Yaba 
FeSV 
III. Animal Pathogens (3) 
A. Animal disease organisms which are for- 
bidden entry into the United States by 
Law iCDC Class 5 agent) 
1. Foot and mouth disease virus 
B. Animal disease organisms and vectors 
which are forbidden entry into the United 
States by USDA Policy tCDC Class 5 
Agents^ 
African horse sickness virus 
African swine fever virus 
Besnoitia besnoiti 
Borna disease virus 
Bovine infectious petechial fever 
Camel pox virus 
Ephemeral fever virus 
Fowl plague virus 
Goat pox virus 
Hog cholera virus 
Louping ill virus 
Lumpy skin disease virus 
Nairobi sheep disease virus 
Newcastle disease virus (Asiatic strains) 
Mycoplasma mycoides (contagious bovine 
pleuropneumonia ) 
Mycoplasma agalactiae (contagious agalac- 
tia of sheep) 
Rickettsia mminatium (heart water) 
Rift valley fever virus 
Rinderpest virus 
Sheep pox virus 
Swine vesicular disease virus 
Teschen disease virus 
Trypanosoma Diraj^(Nagana) 
Trypanosoma evansi 
Theileria parva (East Coast fever) 
Theileria annulata 
Theileria lawrencei 
Theileria bovis 
Theileria Ittrci 
Vesicular exantema virus 
Wesselsbron disease virus 
Zyonema farciminosum (pseudofarcy) 
References 
1. Classification of Etiologic Agents on the 
Basis of Hazard. (4th Edition. July 1974). 
U.S. Department of Health. Education, and 
Welfare, Public Health Service. Center for 
Disease Control, Office of Biosafety. Atlan- 
ta. Georgia 30333. 
2. National Cancer Institute Safety Stand- 
ards for Research Involving Oncogenic Vir- 
uses (October 1974). U.S. Department of 
Health. Education, and Welfare Publication 
No. (NIH) 75-790. 
3. U.S. Department of Agriculture, Animal 
and Plant Health Inspection Service. 
Dated: December 15, 1978. 
Donald S. Fredrickson, 
Director, 
National Institutes of Health. 
Approved: December 15, 1978. 
Julios B. Richmond, 
Assistant Secretary for Health. 
Approved: December 15, 1978. 
Joseph A. Califano, Jr., 
Secretary. 
CFR Doc. 78-35533 Filed 12-21-78; 8:45 am] 
FEDERAL REGISTER, VOL 43, NO. 247— FRIDAY, DECEMBER 22, 1978 
[53] 
