Page 2 - The Honorable Douglas M. Costle 
However, there may be significant recombinant DNA research 
conducted in the private sector which would not be submitted 
to the FDA. For this reason, I hope you will review the 
Environmental Protection Agency regulatory authority and 
take all action EPA can to require that recombinant DNA 
research conducted by the private sector complies with the 
NIH guidelines. 
If both FDA and EPA regulate recombinant DNA research, 
virtually all recombinant DNA research in this nation will 
comply with the revised NIH guidelines which assure pro- 
tection of the public health and the environment. 
I appreciate your willingness to work with us in this task. 
Sincerely 
Joseph A. Califano, Jr. 
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