TABLE OF CONTENTS 
I. GENERAL REQUIREMENTS 1 
I-A. Institutional Biosafety Committee (IBC) 1 
I-B. Prior Approval Requirements 2 
I-B-l. Activities Requiring Prior Approval 2 
I-B-2. Requests for Activities Requiring 
Prior Approval 3 
I-B-2-a. Activities Requiring Prior NIH Approval 3 
I-B-2-b. Activities Approvable by Other Agencies 4 
I-C. Required Registration of Recombinant DNA Projects 4 
I-C-l. NIH-Supported Projects 4 
I-C-2. Non-NIH Projects Supported by Federal 
Agencies 4 
I- C-3. Nonfederally Supported Projects 5 
I-D. Voluntary Registration 5 
II. REQUIREMENTS AND PROCEDURES FOR NIH-SUPPORTED PROJECTS 5 
I I-A. Memorandum of Understanding and Agreement (MUA) 5 
II- A-1. Elements of an MUA 6 
II-A-l-a. Description 
II-A-l-b. Assessment of Containment Levels 
II-A-l-c. Information on Health Surveillance 
II-A-l-d. Statement on Shipping and Accuracy of MUA 
II-A-l-e. Information Concerning IBC Review 
II-A-l-f . Statement Regarding Training and Continuing 
Compliance 
II-A-l-g. Signatures 
II-A-l-h. Date of MUA 
II-A-2. MU As for Recombinant DNA Research at Multiple 
Sites 8 
II-A-3. MU As Associated with Individual Fellowship 
Applications, Research Career Development Award 
Candidates (RCDA) , Research Career Awardees (RCA), 
and National Research Service Fellowship Awards 9 
I I-B. Notation on Applications for Research and Training 
Grants 9 
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