TABLE OF CONTENTS (Cont'd) 
II-C. Submission of Memorandum of Understanding and 
Agreement (MUA) 10 
II-C-1. Gonpeting Applications 10 
II-C-2. Nonccsnnpeting Applications 10 
II-D. Review of MUAs by NIH 11 
II-E. Changes in Ongoing Projects 11 
II-E-1. Protocols for Which Prior NIH Approval Is 
Not Required 12 
II-E-l-a. Major Changes 12 
II-E-l-b. Minor Changes 13 
II-E-2. Protocols for Which Prior NIH Approval 
Is Required 13 
II-F. Shipping Requirements 13 
II-G. Policy and Procedures for Recombinant DNA Research 
Supported by NIH and Conducted in Foreign Countries 14 
II-G-1. Requirements Regarding Countries That Have 
Adopted Guidelines 14 
II-G-2. Requirements Regarding Countries That Have 
Not Adopted Guidelines 16 
II-H. Lowering of Containment Levels for Purified DNA and 
Characterized Clones 16 
II-H-1. Purified DNA Other Than Plasmids, 
Bacteriophages, and Other Viruses 17 
II-H-2. Characterized Clones of DNA Recombinants 17 
II-I. Exceptions to Prohibitions and Exemptions 
from the Guidelines 18 
II-I-l. Exceptions 18 
II-I-2. Exemptions 18 
II-I-3. Requests for Exceptions and Exemptions 18 
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