ADMINISTRATIVE PRACTICES SUPPLEMENT 
POLICIES AND ADMINISTRATIVE PROCEDURES FOR 
RECOMBINANT ENA RESEARCH SUBJECT TO THE NIH GUIDELINES 
This Supplement to the NIH Guidelines applies only to recombinant 
ENA research subject to the Guidelines as revised in December 1978 (See 
Section I-E of the Guidelines for exempt experiments). The policies and 
procedures described here may be superseded by subsequent issuances. 
The NIH Office of Recombinant ENA Activities (ORDA) will publish any 
changes in the Recombinant ENA Technical Bulletin . 
A separate NIH announcement outlines procedures for the transition 
from the 1976 to the 1978 Guidelines. 
I. GENERAL REQUIREMENTS 
The requirements in this section of the Administrative Practices 
Supplement (APS) are mandatory for all recombinant ENA research conducted 
at Institutions receiving any NIH funds for such research. Additional 
requirements for NIH applicants and awardees are to be found in Section II. 
I -A. Institutional Biosafety Committee (IBC) . Each Institution 
involved in the conduct of recombinant DNA research subject to the Guide- 
lines must have a standing Biosafety Committee. Requirements and recom- 
mendations for the composition of such a committee are discussed under 
Part IV of the Guidelines, which also discusses the roles and respon- 
sibilities of Principal Investigators (Pis) and Institutions. 
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