I-C-3. Nonfederally Supported Projects . Institutions receiving 
NIH funds for recombinant DNA research must inform NIH of all ongoing 
nonfederally supported recombinant DNA projects subject to the Guide- 
5 
lines. These projects must be registered with NIH within 30 days of 
initiation of the project. See Section III of this Supplement for regis- 
tration procedures for these projects. 
I- D. Voluntary Registration . An institution that is not receiving 
NIH funds for recombinant DNA research may register with NIH any ongoing 
projects to which the Guidelines are applicable. See Section III of 
this Supplement for registration procedures for such projects. 
II. REQUIREMENTS AND PROCEDURES FOR NIH-SUPPORTED PROJECTS 
This section describes additional requirements for NIH-supported 
projects and applications. The requirements in this section supersede 
announcements in the October 17, 1977, and February 15, 1978, issues of 
the NIH Guide for Grants and Contracts and notices in application 
kits for Public Health Service research and training grants. 
II- A. Memorandum of Understanding and Agreement (MUA) . Each 
research grant application to the National Institutes of Health for a 
project involving experiments subject to the NIH Guidelines for Recom- 
binant ENA Research (see Section I-E of the Guidelines for exempted 
experiments) must be accompanied by an MUA. Applicants are urged to 
follow as closely as possible the sequence and format of the Illustration 
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