11 
NOTE ON REGISTRATION : If an investigator submitting a new 
competing application to NIH and prior to its funding wishes to initiate 
a project upon IBC approval, the procedures for registration of non-NIH 
projects, described in Sections I-C-2, I-C-3, or III-A of this Supple- 
ment, must also be followed. Initiation of new experiments in an ongoing 
project requires that an MUA be filed with NIH within 30 days of IBC 
approval, even if the proposed experiments are also described in an 
MUA submitted with a noncompeting or a competing renewal application 
that may be funded at a later date. In these cases, the procedures 
dealing with changes in ongoing projects, described in Section II-E of 
this Supplement, must also be followed. 
II— D. Review of MU As by NIH . ORDA will review all MUAs for 
projects funded, or about to be funded, by NIH. The Principal Invest- 
igator and the IBC will be notified of the NIH review of the MUA. If 
ORDA finds that an MUA, or certain aspects of it, do not conform to 
standards set forth in the Guidelines, immediate action must be taken to 
bring the protocols into compliance or the experiments in question must 
be suspended. 
II-E. Changes in Ongoing Projects . Changes in a project subject 
to the Guidelines must be reported to the IBC by the Principal 
Investigator. 
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