13 
protocols into compliance or the experiments in question must be 
suspended . 
II-E-l-b. Minor Changes . Principal Investigators should submit 
information on minor changes in research protocols to the IBC. Minor 
changes need not be reported to NIH until an updated MUA is required 
(see Section II-C-2 of this Supplement). 
II-E-2. Protocols for Which Prior NIH Approval Is Required . Prior 
NIH approval is required for changes involving recombinant DNA experi- 
ments described in Section I-B of this Supplement. 
II-F. Shipping Requirements . Certification of compliance with 
requirements for shipment and transfer of recombinant ENA materials may 
be incorporated in the MUA (as shown in item d of the Illustration below) . 
All MU As must indicate that the Principal Investigator (program director, 
fellow, or candidate) agrees to comply with the following provisions: 
II-F-1. Prior to shipment or transfer of recombinant DNA materials 
within the United States, the sending laboratory shall obtain a written 
statement from the requesting laboratory that: 
II-F-l-a. Research involving recombinant ENA molecules shall be 
conducted in compliance with the NIH Guidelines and other NIH instruc- 
tions, and 
[ 76 ] 
