15 
general, be accepted as assurance that the research will be conducted in 
a responsible manner. NIH reserves the right, however, to withhold 
funding if the safety practices to be employed are not reasonably con- 
sistent with the NIH Guidelines. 
The following procedures apply to NIH-supported research in foreign 
countries that have adopted guidelines, whether the investigators are 
U.S. or foreign nationals. For U.S. investigators intending to conduct 
recombinant DNA research abroad, the required documentation (see below) 
must be submitted prior to initiation of the project. For applications 
by foreign nationals, the required documentation may be included with 
the application or submitted at a later date, but it must be submitted 
prior to the time of award. 
In the above cases, a document providing the following information 
must be submitted to NIH: 
II-G-l-a. A description of each proposed project, and the name of 
the individual investigator responsible for the research if other than 
the Principal Investigator. The description must include information on 
the sources of DNA, the nature of inserted DNA sequences, and the hosts 
and vectors to be used. It must provide enough detail to obviate the 
need for reference to other documentation. Ordinarily, each series of 
experiments should require no more than two pages of description. 
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