16 
II-G-l-b. An assessment of the level(s) of physical and biological 
containment required by the guidelines of the country in which the 
research is to be conducted. 
II-G-l-c. Documentation that the research project is in compliance 
with the applicable national guidelines and, where required, has been 
registered with the appropriate national body. If approval of the 
national body is required prior to initiation of the research, the docu- 
mentation must indicate that such approval has been received. 
II-G-l-d. The signatures of both a responsible official and the 
Principal Investigator. 
II-G-l-e. The date of signature of the responsible official. This 
will become the date of the document for future reference. 
II-G-2. Requirements Regarding Countries That Have Not Adopted 
Guidelines . NIH funds may not be used for the conduct of recombinant 
CNA research in a country that has not adopted national guidelines 
unless the research is in full compliance with the NIH Guidelines and 
with the procedures required for U.S. grant applications — i.e., an IBC 
must be established, an MUA filed, etc. 
II-H. Lowering of Containment Levels for Purified DNA and Characterized 
Clones. 
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