2 
Among the revised requirements is that the IBC shall be composed of 
no fewer than five members so selected that they collectively have 
experience and expertise in recombinant DNA technology and the 
capability to assess the safety of recombinant ENA research experi- 
ments and any potential risk to public health or the environment. 
At least two members (but not less than 20 percent of the membership 
of the committee) shall not be affiliated with the Institution 
(apart from their membership on the IBC) and shall represent the 
interest of the surrounding community with respect to health and 
protection of the environment. Members meet the latter requirement 
if, for example, they are officials of State or local public health 
or environmental protection agencies, members of other local govern- 
mental bodies, or persons active in medical, occupational health, 
or environmental concerns in the community. The Biological Safety 
Officer (BSO), mandatory when research is being conducted at the P3 
and P4 levels, shall be a member (see Section IV-D-4). See Section 
IV- D- 2 for additional requirements and recommendations for the 
operations of IBCs. 
All institutions receiving NIH funds for recombinant ENA research 
must file a report with ORDA no later than January 31, 1979, indicat- 
ing that the IBC is in compliance with the requirements of the 
revised Guidelines. Even if an IBC already on file with ORDA meets 
the requirements of the revised Guidelines, a statement to that 
effect must be filed. If new members have been appointed to effect 
this compliance, a revised list of members and additional CVs should 
accompany the report. IBCs will be notified of the review of their 
composition for compliance with the requirements of the revised 
Guidelines. 
Institutions may begin to use the revised Guidelines in accordance 
with procedures in Sections IV and V as soon after January 2, 1979, 
as they have an IBC so constituted that it meets the revised require- 
ments. Prior NIH approval of the IBC membership is not required. 
IV. Ongoing Projects and Adoption of New Containment Levels 
Ongoing projects being carried out under the provisions of the 1976 
Guidelines and covered by approved MUAs on file with NIH should 
continue under the same containment levels until newly executed 
MUAs, specifying containment requirements of the revised Guidelines, 
have been approved by a properly constituted IBC. Institutions 
must then submit the new MUA within 30 days of IBC approval to the 
appropriate program administrator of the awarding NIH Bureau, 
Institute, or Division. The revised MUA must include a reference 
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