4 
MUAs incorporating activities that require prior NIH approval must 
be submitted to NIH by the institutional official to whom the IBC 
is responsible. If the MUA pertains to an NIH-supported project, 
it must be submitted to the program administrator of the awarding 
NIH Bureau, Institute, or Division. The latter will forward the 
request to ORDA. If the MUA pertains to a project supported by 
private funds or to a project funded by an agency not designated 
by NIH as having prior approval authority, the MUA must be submitted 
directly to ORDA with a covering letter explaining the nature of the 
request. 
VI. Exempt Projects 
IBCs should inform ORDA and the appropriate NIH program administrator 
of ongoing projects that are exenpt from the requirements of the 
revised Guidelines, so that these projects may be removed from the 
NIH registry of recombinant ENA projects covered by Guidelines (see 
Section I-E of the Guidelines for exenpt experiments). 
VII. Containment Conditions Specified by NIH 
In a number of cases NIH has stipulated appropriate containment 
levels for experiments that were not specifically considered under 
the 1976 Guidelines and are also not specifically considered in the 
revised Guidelines. Hie containment levels for these experiments 
were specified by NIH after recommendation by the RAC and approval by 
the Director, NIH. Ihese experiments may continue, without new MUAs, 
under the stipulated containment conditions. Requests for changes in 
the stipulated containment conditions must be processed according to 
procedures described in the Administrative Practices Supplement. 
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