27 
1 experiments should be permitted. Thirdly, there are a 
2 series of experiments which should be conducted under 
3 highly controlled P 4 conditions. Recombinant research 
4 with Class 3 etiological agents are not permitted, in 
5 spite of a need to explain basic mechanisms of patho- 
6 genicity with these agents, and in spite of the existence 
7 of a national P 4 facility. 
8 Our greatest need is for good risk analysis, 
g particularly with Class 3 organisms, in which knowledge of 
TO genetic systems is scanty, and where our own need to 
H develop defense mechanisms is the greatest. The need, 
12 for example, to conduct the risk assessments Dr. Wally 
13 Rowe carried out with polyoma virus, with wild type 
14 E. col i is essential in developing national policy. 
15 Thus, we believe it is important that the Director have 
15 such authority, following proper review and availability 
17 of a P 4 facility, to permit such types of experiments. 
18 The final area deals with roles and 
19 responsibilities. This issue concerns the assignment of 
20 responsibility. For the past two years we have supported 
21 the view that substantial responsibility be transferred to 
22 IBC's. We approve of the recommendations in Section IV 
23 of the guidelines to implement this goal. We are convinced 
24 that license revocation and the witholding of federal funds 
25 are both sufficient and effective restraints to effect 
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