5!5 
1 have been suggested for such research would affect many 
2 sectors of society. 
3 Thus, I believe that members of the general 
4 citizenry have a fundamental right to participate in 
5 policy-making and decision-making which goes on in 
6 regard to recombinant DWA research. One of the problems 
7 I have with the guidelines is that I don't think they 
g make adequate provision for this. 
g As a matter of fact, I can say quite clearly 
10 that were the IUC at the University of Washing ton to 
11 follow the model suggested by the guidelines, I think 
12 that our activities would be severely restricted coii- 
13 pared to what we do now, that it would be a substantial 
14 setback in the efficiency of our work and the confidence 
15 with which we are held by members of the general public. 
16 Among my remarks today, I want to talk a 
17 little bit about the notions of risk and safety, mainly 
18 because I think that they are very important in this 
19 whole regulation of recombinant DNA , and because I 
20 think the guidelines confuse the two concepts, and 
21 are not helpful to the IBC's and to the general public 
22 in sorting this out. 
23 The d istinctions between risk and safety have 
24 been set out in the literature. For example a recent 
25 book, "Of Acceptable Risk," by William Lowrence, who is 
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