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contrary, the expression of eukaryotic DMA in bacteria, 
exhibited in such experiments as the successful insulin 
production work, prove that higher and lower organism 
gene boundaries can and will be crossed by man. The 
Rowe-Martin experiment shows that naked DMA far from 
being inactive, does infect cells. Unsubstantiated 
claims of the safety of recombinant DNA research 
pervade the Director's Decision Document, and the 
Environmental Assessment Document, and are reflected 
in these new proposed guidelines. 
We strongly believe that the containment 
measures are too lax and should be increased in order 
to protect health and environment. By delegating 
increased authority to IBC's and allowing them wide 
discretion in setting containment levels, the proposed 
guidelines insure confusion and disrespect in the 
implementation of the guidelines. A uniform set of 
guidelines is a necessity for the safe conduct of 
recombinant DHA research. 
Finally, provisions for reinforcement of the 
guidelines are inadequate. NIH should enforce the 
guidelines and monitor its grants for recombinant DNA 
research. Yet, the revised guidelines delegate respon- 
sibility for inspection and oversight to the IBC's. 
This, we believe is an improper abrogation by NIH of 
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