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1 for the introduction of foreign genes into eukaryotic 
2 cells. While that symposium did not in itself directly 
3 address recombinant DNA, many of the results and ideas 
4 which were discussed at that symposium involved recom- 
5 binant DNA technology. 
6 I think, therefore, that while there are 
7 many areas covered by the guidelines in which I have 
8 no direct expertise, I have certain knowledge which 
9 allows me to make evaluations of the proposed revisions 
10 to the guidelines. 
11 Obviously it is impossible to remove all this 
12 from research by regulation or otherwise. In the case 
13 of recombinant DNA, we know of no known risks. The 
14 guidelines resulted from the thoughts of a group of 
15 scientists who were concerned about the potential risks 
16 of recombinant DNA. They therefore proposed that these 
17 potential risks be considered further before research 
18 with recombinant DNA proceeded. 
19 Careful consideration of those potential risks 
20 has not, to my knowledge, resulted in any scenario which 
21 is likely under the guidelines to lead to substantial 
22 risk to the population. It is my belief that the proposed 
23 revisions to the guidelines also provide no substantial 
24 increase in risk to the laboratory worker or to the public. 
25 On the other hand, they do substantially 
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