issue, largely owing to the lack of a concise meaning for pathogen and poly- 
peptide toxin mentioned throughout the Guidelines. We also question the 
necessity for EPA registration of an entomopathogenic organism in lieu of 
simply meeting the criteria of EPA for a temporary exemption from a require- 
ment of tolerance in the environment. Lastly, we would suggest that the NIH 
clarify the meaning of a PI insect proof greenhouse in regards to cloning 
genes in plants. We believe it is virtually impossible to have a PI facility 
that is insect proof and still remain classified as PI. 
[ 305 ] 
