TELEGRAPHIC MESSAGE 
DEPARTMENT OF HEALTH, EDUCATION, AND 
WELF ARE/OS/EXSEC 
PRECEDENCE 
ACTION 
INPO: 
SECURITY CLASSIFICATION 
ACCOUNTING CLASSIFICATION 
8-1990351 7580120 
DATE PREPARED 
October 13, 1978 
FO« information cau 
name 
Richard Cotton 
PNONE NUMBER 
245-7462 
TYPE OF MESSAGE 
Q3 SINGLE 
□ BOOR 
| | MULTIPLE-AOORESS 
THIS SPACE FOR USE OF COMMUNICATIOS UHIT 
MESSAGE TO M TRANSMITTED / Lu dsubi* tp+£rng *md mil capital UttmJ 
TO: 
DR. HAMILTON 0. SMITH 
JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE 
725 N. WOLFE STREET 
BALTIMORE, MARYLAND 20205 
I LEARNED OF THE AWARD OF THE 1978 NOBEL PRIZE FOR MEDICINE TO YOU 
WITH A DEEP FEELING OF NATIONAL PRIDE AND WITH ADMIRATION FOR YOUR 
ACCOMPLISHMENTS . 
YOUR KEY CONFIRMATION OF THE ORIGINAL DISCOVERY OF RESTRICTION 
ENZYMES — AND YOUR SUBSEQUENT WORK WITH THESE ENZYMES — HAS LED TO 
THEIR USE IN IMPORTANT RECOMBINANT DNA RESEARCH CARRIED OUT THROUGHOUT 
THE WORLD. RESTRICTION ENZYMES ARE NOW BEING USED IN HUNDREDS OF 
LABORATORIES TO STUDY THE STRUCTURE OF DNA — WORK THAT MAY ULTIMATELY 
HELP US UNDERSTAND THE DIFFERENCE BETWEEN NORMAL CELLS AND CANCER CELLS 
YOUR ASSOCIATION WITH THE RESEARCH PROGRAMS OF THIS DEPARTMENT OVER 
THE YEARS IS A SOURCE OF GREAT PRIDE TO US. 
YOUR EFFORTS RICHLY DESERVE THE HIGH RECOGNITION YOU HAVE NOW 
RECEIVED, AND I OFFER MY MOST RESPECTFUL, PERSONAL CONGRATULATIONS 
ff. 
JOSEPH A. CALIFANO, JR. 
/ SECRETARY OF HEALTH , 
{ y EDUCATION, AND WELFARE 
PAGE NO no of pgs 
ii»»:»i: fopm i« 
*1- IK A V-'S* It’ 
\* »F-I .41 C*». 101. JJ 104 
S£CU*TTY CLASSIFICATION 
[ 421 ] 
