NORTHWESTERN UNIVERSITY 
EVANSTON, ILLINOIS 60201 
DEPARTMENT OF BIOCHEMISTRY 
AND MOLECULAR BIOLOGY 
August 10, 1978 
Dr. Donald S. Fredrickson 
Director 
National Institutes of Health 
Bethesda, Maryland 20014 
Dear Dr. Fredrickson: 
I have carefully read the Proposed Revised Guidelines for recombinant 
DNA research. I consider the proposed revisions to be a dramatic improvement 
of the original guidelines. It is especially encouraging to see the recognition 
of the effectiveness of biological containment. The original guidelines have 
served their purpose, and are now unnecessarily impeding progress. I urge 
you to institute the revised guidelines as soon as possible. 
Sincerely 
Lawrence B. Dumas 
Associate Professor 
LBD/jd 
[A-8] 
