ROCHE INSTITUTE OF MOLECULAR BIOLOGY 
NOTLEV, NEW JERSEY 07110 
August 16, 1978 
Dr. Donald S. Freder ickson, Director 
National Institutes of Health 
Building 1, Room 124 
9000 Rockville Pike 
Bethesda, Maryland 20014 
Dear Dr. Freder Ickson : 
I would like to take this opportunity to comment on the recent revised 
guidelines for recombinant DNA research. It la obvious that careful thought 
had gone Into this document and the suggested changes make good sense In 
light of the knowledge that has been gained over the past two years. 
As chairman of the Hoffmann-La Roche recombinant DNA biosafety committee, 
I cannot emphasize how Important these guidelines are for those of us in 
industry who are involved In this area of research. I see no reason why the 
entire scientific community, academic or industrial, shouldn't endorse this 
document. Those Involved in putting these guidelines together deserve our 
wholehearted thanks. 
Sincerely, 
Herbert Weissbach, Ph.D. 
Associate Director 
HU :bk 
[A-17] 
