MASSACHUSETTS INSTITUTE OF TECHNOLOGY 
CENTER FOR CANCER RESEARCH 
Room £17-539 
77 Massachusetts avenue, cammidce. Massachusetts onw 
Tel. 617/253-3015 
August 16, 1978 
Dr. Donald Frederlckson 
Director, N1H 
Building 1 - Room 124 
9000 Rockville Pike 
Bethesda, MD 20014 
Dear Dr. Frederlckson: 
This letter responds to the request for consents on the proposed 
revised guidelines for reconblnant DNA research Issued July 28. 
The guidelines appear reasonable in light of present knowledge 
and the relaxations in particular fully merited by the data available. 
Requiring no mouth plpetlng at the P-1 level enforces good laboratory 
practice for protection of workers (largely from discomfiture). 
I hope that as experience grows and - as I expect - the safety 
of this research is even better demonstrated that we will see continued 
cutting of the red tape developed for recombinant DNA research and 
either dismantling of the bureaucracy developed to cope with it or 
redirecting of it towards biohazards of greater potential. 
Sincerely 
Michael D. Garrick 
Assoc . Prof. Blochem. and 
Res. Assoc. Prof. Pediatrics 
SUNT Buffalo 
On study leave 
MDG/srp 
[A-21] 
