ENVIRO CONTROL, INC. 
One Central Plaza 
11300 Rockville Pike 
Rockville, Maryland 20852 
Telephone: 301 -468-2500 
August 17, 1978 
Dr. Donald S. Fredrickson 
Director, National Institutes of Health 
Bethesda, Maryland 20014 
Dear Dr. Fredrickson: 
The purpose of this letter is to provide comment on certain 
elements of the Proposed Revised Guidelines for Recombinant 
DNA Research published in Part IV of the Federal Register for 
Friday, July 28, 1978. 
The comments offered are: 
1. It is suggested that the terminology forking area" (Ref. 
para. II-B-1 -a-(5) ) and "laboratory area" (Ref. paras. 
II-B-2-a-(5) and II-B-3-a-(5) ) be clarified. The use of the 
two different terms in describing the prohibited locations and 
the word area are felt to be unclear and thus subject to 
varying interpretations. 
It is suggested that the cited paragraphs be changed to 
read, "Eating, drinking, smoking, or the storage of food are 
not permitted in the laboratory's ) or other rooms in the 
facility in which recombinant DNA materials are handled." 
The suggested revised wording is offered since it extends 
the prohibition to all spaces in a facility in which recom- 
binant DNA materials may be handled, e.g., instrument rooms, 
glassware, refrigeration equipment rooms, etc. 
2. It is suggested that the second sentence of paragraphs 
I I -B-2-a- (1 1 ) and I I-B-3-a-(l 1 ) be amended to read - 
Freezers, refrigerators, or other units used to store. . .. 
The insertion of the words "other units" provides for 
includinq all possible storage units while using the words 
freezer and refrigerator to typify such units. 
[A-22] 
