VAN WERT • SNYDER • SKLARSKY • ROWLEY 
ARCHITECTS/CONSULTING ENGINEERS 
1965 Sheridan Drive. Buflalo. New York 14223, (716) 877-3350 
PARTNERS 
Paul H Van Wert. A I A 
Julian Snyder. P E Ph D 
Richard A Sklarsky. P E 
Donald H Rowley. P E 
Department of Health, Education and Welfare 
Public Health Service 
National Institutes of Health 
Bethesda, Maryland 20014 
Attn: Dr. Donald F. Fredrickson, Director 
ASSOCIATES 
Harvey W. Anderson 
Anthony J Cartonia. Jr., A I.A 
John P Hutten 
Raymond F. Johnson 
Victor E. Summerfield 
CONSULTANTS 
Edward Bond. P E 
Arthur Boswell. P E 
Gentlemen: 
Appreciate receipt of July 28th Federal Register covering Proposed Revised Guidelines 
for Recombinant DNA Research. Our firm is deeply involved with the use of these 
guidelines in preparing working drawings for the National Biomedical Containment 
Laboratory at Frederick Cancer Research Center and I consider it an honor to accept 
your invitation to submit comments on the proposed revisions. 
In addition to the suggestions contained herein, I have also enclosed a tabulation of the 
physical containment portion of the guidelines covering Laboratory Practice, Containment 
Equipment and Special Laboratory Design. This document was prepared by our office to 
assist our staff in comprehending and comparing the various requirements at a glance. 
Needless to say, it has proven most valuable not only in our design work on the above 
project, but also on the Cancer Research Containment Facility recently prepared for 
Roswell Park. I submit it to you hoping you may find it useful as a handy reference. 
Comments on the Proposed Revised Guidelines are referenced to Federal Register page 
numbers as follows: 
1. Page 33074, Section II— B— 4— a— (14) 
In listing the required laboratory clothing included, I noted that gloves have 
been deleted. It would seem that the use of gloves would be utmost important 
in P-4 work since they are required in P-3 labs. 
Later in this same paragraph, it refers to "discarding contaminated clothes into 
collecting hampers" but does not indicate that these clothes should be decon- 
taminated before being sent to the laundry. 
[A-29] 
Formerly "Office of J. Fruchtbaum Associates 
