Department of Energy 
Washington, D.C. 20545 
Dr. Joseph G. Perpich 
Associate Director for 
Program Planning and Evaluation 
Department of Health, Education, and Welfare 
National Institutes of Health (NIH) 
Bethesda, Maryland 20014 
Dear Dr. Perpich: 
As requested in your letter of August 7, 1978, documents supporting 
the Proposed Revised Guidelines to control recombinant DNA research 
funded by the NlH have been reviewed and the following comments are 
submitted. 
1. No specific changes are proposed to the Revised Guidelines as 
published in the Federal Register (Part IV) on Friday, July 28. 
2. I believe the Guidelines to be fully adequate to protect the 
public and the environment from any hazards associated with 
recombinant DNA research. 
3. I concur in the conclusion of the Environmental Impact Statement 
(EIS) that "there would be no adverse impact upon the environment 
of the NIH-proposed changes in the Guidelines." 
Thank you for the opportunity of reviewing the Proposed Revised 
Guidel ines. 
Sincerely, 
Walter H. Weyzen, Manager 
Human Health Studies Programs 
Division of Biomedical and 
Environmental Research 
[A-31] 
