THE UNIVERSITY OF CHICAGO 
COMMITTEE ON GENETICS 
920 EAST 5 8 T H STREET 
CHICAGO • ILLINOIS 60637 
August 24, 1978 
Dr. Donald S. Frederickson 
Director, National Institutes of Health 
Building 1, Room 124 
Bethesda, Maryland 20014 
Dear Dr. Frederickson: 
I write to express my approval of the new Guidelines for Recombinant DNA 
Research recently published in the Federal Register. These revised guide- 
lines strike a reasonable and realistic balance between risks and benefits. 
We do not know what dangers, if any, can be expected from new recombinant 
DNA experiments. The restrictions will provide adequate safeguards to 
prevent harm. On the other hand, the proposed guidelines allow a reason- 
able reduction in the restrictions so that work of great scientific interest 
and potential benefit can proceed expeditiously. I urge that these revised 
guidelines be adopted. 
Chairman 
WE/gb 
[A-40] 
