Page two 
Dr. Fredrickson 
August 28, 1978 
It is my further understanding that Caulobacter was excluded from the 
new guidelines because of a lack of published material concerning the above- 
mentioned experiments describing intergeneric exchange. Dr. Ely's manuscript 
describing this data has been submitted. In my opinion, after careful review, 
the manuscript appears to be well-documented and contains nothing which should 
impede its speedy acceptance and subsequent publication. It is my further 
understanding that intergeneric exchange in some of the organisms already 
included in the revised guidelines, Agrobacterium for example, is not as 
extensively described as that for C. crescentus. 
I hope that you will find it possible to review the data and add Caulobacter 
to the new guidelines as it will substantially facilitate research which by all 
available criteria should be exempt under the proposed revision of the NIH 
guidelines on recombinant DNA. 
Very truly yours. 
NA:kg 
[A-56] 
