THE UNIVERSITY OF NORTH CAROLINA 
AT 
CHAPEL HILL 
Division of Health Affairs 
The School of Medicine 
Department of Bacteriology and Immunology 
The University of North Carolina at Chapel Hill 
804 Faculty Laboratory Office Building 231 H 
Chapel Hill, N.C. 27514 
August 29, 1978 
Dr. Donald S. Fredrickson 
Department of Health, Education and Welfare 
Public Health Service 
National Institutes of Health 
Bethesda, Maryland 20014 
Dear Dr. Fredrickson: 
Although I am a scientist who was until recently only passively 
interested in the new recombinant DNA technology, I have welcomed 
the cautious approach taken by the government in establishing 
appropriate guidelines for investigators who wish to perform these 
experiments. In fact since the guidelines first appeared I have 
seen my own research area rapidly develop into one where the 
recombinant technology can be extremely useful. I have also 
followed with concern the criticisms of many oponents to this 
type of research. 
I have recently studied the proposed revisions of these 
guidelines and am writing to express my wholehearted approval. 
I appreciate the fact that there will be guidelines and that 
known hazardous experiments will be restricted to appropriate 
research facilities but that the revisions will not become 
obstacles to interfere with simple manipulation with recombinant 
molecules or to the advancement of science. Please register my 
complete support of the revisions and accept my personal thanks 
for the tremendous contribution you have personally made toward 
the advancement of science by over-seeing the drafting revision 
and re-revision of the guidelines. 
Sincerely yours 
Kenneth F. Bott 
Associate Professor 
