HOFFMANN -LA ROCHE INC. 
NUTUEY . NEW JERSEY 07110 • TELEPHONE (200 235-5000 • (N. Y. C.) 695 -I.AOO 
RESEARCH DIVISION 
August 30, 1978 
Dr. Donald S. Frederickson, Director 
National Institutes of Health 
Bethesda, Maryland 
Dear Dr. Frederickson: 
In consideration of the Federal Register announcement of 
July 28, 1978, I wish to urge that experiments involving 
recombinant DNA technology be permitted in species of the 
genus Streptomyces . This group of microorganisms has an 
enormous importance in the production of antibiotics, the 
strains can be handled without presenting a hazard to human 
health, and genetic exchange has been demonstrated among 
several species of the genus. Recombinant DNA experiments 
could in the near future add a new dimension to the 
methodology for strain improvement. 
Sincerely y<purs, 
•V / 
f l / ^ 
1 1 \ \ ^ 
Norberto AT. Palleroni, 
Curator ®f tne Microbial Collection 
Chemical ^Research Division 
NJP: rib 
[A-63] 
