- 3 - 
There are many more issues that one could expound upon, both adminis- 
tratively and technically. Recombinant DNA research is still in an 
infant state and the guidelines are bcund to be fallible. There will 
be mistakes, additions, and deletions. One can only foresee the im- 
plications and results, and control thse aspects through due process. 
The purpose of my second comment is to make one more aware of the needs 
of the future and what must eventually be. 
I am satisfied with the technical aspects of the guidelines. The proper 
measurements of safety have been taken in order to carry out successful 
research. This will be based upon hew well the researchers are trained 
with the guidelines as a means of standardization. Hopefully, this will 
serve as a base for future federal regulations in order to provide safe, 
and yet efficient research. 
Sincerely yours, 
Michael J. Differ io 
Administrator , Research & Development 
MJD:et 
[A-73] 
