O' 
ta j Proposed Rerised Guidelines oontlnuad 
pegs 2 
Possible Series of Brants Hhioh Could Lead to Pathogenioity of E. ooli I^ 2 
innocuous B. ooli rector 
l 
laboratory disposal unit 
sewage 
I 
island waterways (st reams; rlrers eto.) 
oo&st&Y waters 
E. ooli E^g ▼•otor oontaining "riral genome or subgenoaio 
fragments of ritually any virus" would be exposed tot 
l 
human waste oontaining large amount of 
unaltered normal intestinal B. ooli 
transferenoe of genetio information 
v between S. ooli K. and unaltered E. ooli 
E. 
exposure to low lerels of radiation and heat from 
nuolear power generators (rate of mutation?) 
exposure to non-biodegradable heary metals (rate ef mutation?) 
ooli ingested by "bottom dwellers" (polyoheate worms) 
l 
polyoheate worms Ingested by "bottom fishes" 
(flounder, ood, pollack eto.) 
I' 
Human Consumption ^ 
seepage of E. ooli baok 
into coastal aquifers 
drinking water 
[A-97] 
