not go unpunished as happened with the two reported violations 
of the 1976 guidelines. Such sanctions could include a fine 
imposed as a percentage reduction of the grant, removal of 
the principal investigator from the project, or NIH takeover of 
the functions of a poorly run IBC. IBCs should also be required 
to develop a plan for sanctions which the institution can and 
will impose. 
CONCLUSIONS 
The proposed reduction in containment requirements is 
not warranted by the scientific information now available 
on risks. A comprehensive assessment of risks must be completed 
before any such reduction is implemented. 
The proposed administrative changes exacerbate the 
problems of self regulation. HEW should supervise administration 
and enforcement of the guidelines. 
[A-207] 
