Dr. Donald Fredrickson 
Page 5 
September 22, 1978 
Recombinant DNA Advisory Committee, after appropriate notice and 
opportunity for public comment, finds that they do not present a 
significant risk to health or the environment." The Guidelines, 
in our opinion, should not be rigid or require the Director of 
NIH to resort to time-consuming and bureaucratic procedures in 
order to change them when changes are necessary to reflect in- 
creased knowledge and experience with recombinant DNA research. 
Sincerely, 
Murray D. Welch, Jr. 
P r 
[A-260] 
