72 Jane Street 
New York N Y 10014 
(212) 675-7173 
Coalition for Responsible Genetic Research 
ADVISORY COUNCIL 
John S. Bird M D. 
Dr. Irwin Bross 
Helen Caldicott M.D.* 
Dr. Liebe Cavalieri* 
John C. Cobb M.D.* 
Dr. Douglas DeNike 
Dr Key Dismukes* 
W. Jack Frumin M.D 
Solomon Garb M.D.* 
Steven Havas M.D.’ 
Dr Ruth Hubbard* 
Dr. Marvin Kalkstein* 
J.R. Kent M.D, 
Dr. Jonathan King* 
Dr. Sheldon Krimsky* 
Elliot Linzer* 
Pamela Lippe* 
Joyce Milton 
Lewis Mumford* 
Dr Stuart Newman* 
Christine Oliver M.D.* 
David Ozonoff M.D.* 
Dr. Barbara Rosenberg* 
David Straton M.D.* 
Dr. George Wald*, 
Nobel Laureate 
Susanna Waterman* 
Dr. Joseph Weizenbaum* 
Dr. Susan Wright* 
* Executive Committee 
MEMBERSHIP: 
PARTIAL LISTING 
Walter Askinas M.D. 
David R. Brower 
Rev. Roger Burgess 
Sir MacFarlane Burnet, 
Nobel Laureate 
Stuart Chase 
Citizens Rights Committee 
Clen C. Cobb M.D. 
Dr. C. David Elm 
William D. Furst M.D. 
Reverend David A. Furuness 
Mariano L. Galaineva M.D. 
W.B. Gamble Jr. M.D. 
F.M. Golomb M.D. 
Dr. Mario A. Gonzalez 
Harold J. Harris M.D. 
Dr. Kenneth L. Jackson 
Father Walter T. Kelleher 
Hadley Kirkman M.D. 
Dr. Laura Kratz 
Henry D. Lauson M.D. 
Dr. Herbert Manning 
Edwin F. Matthews Jr. 
Edward Miller M.D. 
Robert Murphy M D. 
Maurice L. Origenes M.D. 
Dr. Aurelio Peccei 
Henry Pinkerton M.D. 
Eliot Porter 
Dr. Jerome Prager 
Dr. Steven Price 
Sister Mary E. Reichert 
Abby Rockefeller 
Lewis M. Schiffer M.D. 
Solomon Garb M.D. 
Membership Secretary 
Francine R. Simring 
Executive Director 
September 22, 1978 
Dr. Donald Fredrickson 
Director 
National Institutes of HEalth 
Bethesda, Md. 20014 
Dear Dr. Fredrickson: 
Enclosed herewith are the comments of our organization 
on proposed revisions of the guidelines for recombin- 
ant DNA research as published in the Federal Register, 
July 28, 1978. A detailed technical analysis of the 
experimentation will follow under separate cover. 
We trust that careful perusal by you. Secretary Califano, 
Mr. Peter Le Bassi, Dr. Henry Aaron, Dr. Julian Richmond, 
et al. of the many points we make in the public health 
interest will result in their incorporation into the guide- 
lines and will help formulate the structures and procedures 
for impartial regulation of recombinant DNA activities. 
We wish at this time to urge once more that any revisions 
that weaken the guidelines be post-poned pending risk assess- 
ment data upon which such revision should be based . At the 
present time such materials are not available. 
With thanks for your kind consideration in this salient pub- 
lic matter. 
FRS:fh 
cc: Le Bassi, Aaron, Richmond 
Kennedy, Stevenson, Ottinger 
Yours very tr uly, 
Franciner Robinson Simring 
Executive Director 
[A-282] 
