Natural Resources Defense Council, Inc. 
Washington Office 
917 15TH STREET, N.W. 
WASHINGTON, DC. 2OOO5 
202 7J7-5OOO 
2345 YALE STREET 
PALO ALTO, CALIFORNIA 94306 
415 3*7-1080 
September 22, 1978 
New York Office 
122 EAST 42ND STREET 
NEW YORK, N.Y. IOO17 
212 949-OO49 
Secretary Joseph Califano 
Department of Health, Education and 
Welfare 
200 Independence 
Washington, D. C. 20201 
Dear Secretary Califano: 
Enclosed are the Natural Resources Defense Council's 
comments on the proposed revised Guidelines for Recombinant 
DNA Research (43 FR 33042, July 28, 1978). In them we raise 
the same questions about the scientific basis for the 
proposed revision and the effectiveness of the enforce- 
ment sections that we raised with you in our meeting last 
May. You and your staff may be interested to read a more 
detailed discussion of these issues. 
We appreciate the attention that you have devoted to 
this issue and your decision to have members of HEW parti- 
cipate in the recent DNA hearings. 
MJC : s ja 
Enclosure 
Marcia J. Cleveland * 
Staff Attorney 
[Enclosure printed on page A-175.] 
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'<»% Recycled Paper 
[A-293] 
