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Coalition for 
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ADVISORY COUNCIL 
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Or Stuart Newman* 
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Susanna Waterman* 
& Joseph Weizenbaum* 
Or Susan Wnght* 
*£*e cutive Committee 
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Eaecufive Director 
TECHNICAL ANALYSIS AND COMMENTS 
ON PROPOSED REVISED GUIDELINES FOR RECOMBINANT DNA 
RESEARCH 
FEDERAL REGISTER, JULY 28, 1978 
PART IV 
INTRODUCTION 
This section of comments on proposed revisions concerning 
the technical aspects of recombinant DNA experimentation is the 
second of a three-part report submitted by the Coalition for 
Responsible Genetic Research. 
Part I - Structures and Procedures 
Part II- Technical Analysis and Comments 
Part Ill-Protection of Employees 
A. "Exchanges" 
The proposed revised guidelines contain a list of prokary- 
otes which are purported to be "exchangers"; i.e. they can ei- 
ther be shown to exchange chromosomal DNA in the laboratory, or - 
their DNA homology is 20% or greater (pp. 33089, 33158). Recom- 
binant DNA from any organism on the list would be permitted to be 
propagated in any other organism on the list. This kind of work 
would be exempt from the Guidelines. 
1. Most of the organisms are listed by genus , when the 
available evidence only addresses possible exchanges between 
particular species of any of the genera . The extent of inter- 
species exchange within the genus Pseudomonas has not even been 
well-characterized. Only organisms designated by species can 
[A-325] 
