III. GUIDELINES 
By way of general comment, the tables are informative and 
much easier to read than the body of the narrative. The overall 
document could use a few more such devices to break up the mass 
of small type. 
IV. ROLES AND RESPONSIBILITIES 
I support the name change to Institutional Biosafety Committee. 
This modification more accurately reflects the intent of the 
Guidelines. A specific suggestion for IV.A.4.f. — incorporate 
the material cited in the second paragraph of this letter. 
Overall, Section IV is a well done and worthwhile part of the 
Guidelines . 
APPENDICES 
My only comment here is that Appendix C is a very necessary part 
of the Guidelines. In Section I of the Guidelines there should be 
a brief mention of each of the appendices. In regards to Appendix 
C, it should be stated in Section I that Appendix C is mandatory. 
ENVIRONMENTAL IMPACT ASSESMENT 
After having, thoroughly read all of the documents pertinent 
to the Guidelines and the EIA, I am convinced that the environ- 
mental impact of recombinant DNA technology will be, on balance, 
highly beneficial. And in comparison to other existing technologies, 
DNA work has relatively little adverse impact. 
LABORATORY MONOGRAPH 
Due to the breadth and depth of this monumental work I have 
only skimmed it. The parts that I have read thoroughly are quite 
well done. 
Sincerely, 
[A-386] 
