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Coalition for Responsible Genetic Research 
ADVISORY COUNCIL 
John S Bird M D 
Dr Irwin Bross 
Helen Caldicott MD' 
Dr liebe Cavalien* 
)ohn C Cobb M D * 
Dr Douglas DeNike 
Dr Key Dismukes* 
W lack Frumin M D 
Solomon Garb M D * 
Steven Havas MD' 
Dr Ruth Hubbard* 
Dr Marvin Kalkstein* 
I R Kent M D 
Dr Jonathan King* 
Dr Sheldon Krimskv* 
Elliot Linzer* 
Pamela Lippe* 
loyce Milton 
Lewis Mumford* 
Dr Stuart Newman* 
Christine Oliver MO* 
David Ozonoff M 0 * 
Dr Barbara Rosenberg* 
David Straton M D * 
Dr Ceorge Wald*. 
Nobel Laureate 
Susanna Waterman* 
Dr loseph Weizenbaum* 
Ch Susan Wright* 
•fiecudve Committer 
September 28, 1978 
Mr. Peter Llbassl 
General Counsel 
H.E.W. 
200 Independence Avenue SW 
Washington, D. C. 
Dear Mr. Llbassl: 
Enclosed herewith are comments on the proposed revised 
Guidelines for recombinant DNA research (July 28, 1978) 
submitted to the National Institutes of Health Director 
Donald Fredrickson by our organization. 
The three sections of our comments are divided as follows: 
Part I - Structures and Procedures 
Part II - Technical Analysis and Coaments 
Part III - Protection of Employees 
We strongly urged Dr. Fredrickson that great consideration 
be given to the following: 
MEMBERSHIP 
PARTIAL LISTINC 
Walter Aik inas M D 
David R Brower 
Rev Roger Burgeit 
Sir MacFarlane Burnet. 
Nobel Laureate 
Stuart Chase 
Citizens Rights Committee 
Clen C Cobb M O 
Dr C David Elm 
William D Furst M D 
Reverend David A Furuness 
Mariano L Galameva M D 
W B Camble Ir M D 
F M Golomb M D 
Dr Mario A Gonzalez 
Harold I Harris M D 
Dr Kenneth L lackson 
Father Walter T Kelleher 
Hadley Kirkman M D 
Dr Laura Kratz 
Henry D Lauson M D 
Dr Herbert Manning 
Edwin F Matthews |r 
Edward Miller M D 
Robert Murphy M O 
Maurice L Origenes M D 
Dr Aurelio Peccei 
Henry Pinkerton M D 
Eliot Porter 
Or Jerome Prager 
Dr Steven Price 
Sister Mary E Reichert 
Abbv Rockefeller 
Lewis M Schiffer M D 
Solomon Carb M D 
Membership Secretary 
Franc me R Simring 
fiecuf/ve Director 
1. that proposed technical revisions await experi- 
mental data to justify weakening any standards; 
2. that the Recombinant DNA Advisory Committee be 
expanded to comply with the Federal Advisory Com- 
mittee Act which requires a "balance of views". 
That the September 15, 1978 hearing was sponsored and chaired 
by officials of HEW, rather than by those of NIH whose function 
it is to promote and fund recombinant DNA research, was an aid 
to a more objective approach. We trust that the review of com- 
ments by HEW officials, such as yourself, will expand that ob- 
jective approach to embrace caution and care in those amounts 
necessary to protect the public health against the potential 
hazards of this new, untried technology. 
Please do not hesitate to call upon us for any help that we 
may provide. 
cc: Kennedy, Stevenson 
Ottinger, Rogers 
FRS:fh 
Yours very truly , 
LUC C 
Francine Robinson Simring 
Executive Director ^ 
[Part I printed on page A-175.] 
[A-397] 
