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Coalition for Responsible Genetic Research 
ADVISORY COUNCIL 
John S. Bird M.D. 
Dr. Irwin Bross 
Helen Caldicott M.D.* 
Dr. Liebe Cavalieri’ 
John C Cobb M D ’ 
Dr. Douglas DeNike 
Dr. Key Dismukes* 
W. Jack Frumin M.D. 
Solomon Garb M.D.* 
Steven Havas M.D * 
Dr. Ruth Hubbard* 
Dr. Marvin Kalkstein* 
J R. Kent M.D. 
Dr. Jonathan King* 
Dr. Sheldon Krimsky* 
Elliot Linzer* 
Pamela Lippe* 
Joyce Milton 
Lewis Mumford* 
Dr. Stuart Newman* 
Christine Oliver M D.* 
David Ozonoff M.D.* 
Dr. Barbara Rosenberg* 
David Straton M D." 
Dr George Wald*, 
Nobel Laureate 
Susanna Waterman* 
Dr. Joseph Weizenbaum* 
Dr. Susan Wright* 
‘Executive Committee 
MEMBERSHIP: 
PARTIAL LISTINC 
Walter Askinas M.D. 
David R. Brower 
Rev. Roger Burgess 
Sir MacFarlane Burnet, 
Nobel Laureate 
Stuart Chase 
Citizens Rights Committee 
Glen C. Cobb M.D. 
Dr. C. David Elm 
William D Furst M.D. 
Reverend David A. Furuness 
Mariano L Galaineva M.D 
W.B. Gamble Jr M.D 
F.M. Golomb M.D. 
Dr. Mario A. Gonzalez 
Harold J Harris M.D. 
Dr. Kenneth L. Jackson 
Father Walter T. Kelleher 
Hadley Kirkman M.D. 
Dr. Laura Kratz 
Henry D. Lauson M.D. 
Dr. Herbert Manning 
Edwin F. Matthews Jr 
Edward Miller M.D. 
Robert Murphy M D. 
Maurice L. Origenes M.D. 
Dr Aurelio Peccei 
Henry Pinkerton M.D. 
Eliot Porter 
Dr. Jerome Prager 
Dr Steven Price 
Sister Mary E Reichert 
Abby Rockefeller 
Lewis M. Schiffer M.D 
Solomon Carb M.D. 
Membership Secretary 
TECHNICAL ANALYSIS AND COMMENTS 
ON PROPOSED REVISED GUIDELINES FOR RECOMBINANT DNA 
RESEARCH 
FEDERAL REGISTER, JULY 28, 1978 
PART IV 
VmOVUCTlON 
This section of comments on proposed revisions concerning 
the technical aspects of recombinant DNA experimentation is the 
second of a three-part report submitted by the Coalition for 
Responsible Genetic Research. 
Part I - Structures and Procedures 
Part II- Technical Analysis and Comments 
Part Ill-Protection of Employees 
A. "Exchcinq&ti" 
A 
The proposed revised guidelines contain a list of prokary- 
otes which are purported to be "exchangers"; i.e. they can ei- 
ther be shown to exchange chromosomal DNA in the laboratory, or 
their DNA homology is 20% or greater (pp. 33089, 33158). Recom- 
binant DNA from any organism on the list would be permitted to be 
propagated in any other organism on the list. This kind of work 
would be exempt from the Guidelines . 
1. Most of the organisms are listed by genus , when the 
available evidence only addresses possible exchanges between 
particular species of any of the genera . The extent of inter- 
species exchange within the genus Pseudomonas has not even been 
well-characterized. Only organisms designated by species can 
Francine R. Simring 
Executive Director 
[A-398] 
