2 . 
under which carriers will accept shipments and is more properly viewed 
as binding the carrier rather than the shipper. Moreover, tariff 
provisions sometimes vary from regulatory requirements. The references 
to tariff restrictions in the Monograph should be adequate. 
5. In view of the above, we would suggest the following text for II-C 
of the revised guidelines: 
II-C. Shipment . Recombinant DNA molecules may be shipped only as 
an etiologic agent under requirements of the U.S. Public Health Service 
and the U.S. Department of Transportation (Section 72.25, Part 72, 
Title 42, and Sections 173. 386-. 388, Part 173, Title 49, U. S. Code of 
Federal Regulations) as specified below: 
II-C-1. Recombinant DNA molecules, contained in an organism or 
virus, when offered for transportation or transported, are subject to 
all requirements of Section 72. 25(c) (1) — (5) , Part 72, Title 42 CFR, and 
Sections 173.6 387-. 388, Part 173, Title 49 CFR. 
II-C-2. Recombinant DNA molecules, contained in an organism or 
virus which is a viable host or vector organism requiring P4 physical 
containment, when offered for transportation or transported, are also 
subject to Section 72.25(c)(6), Part 72, Title 42 CFR. 
II-C-3. Other recombinant DNA molecules, when offered for transpor- 
tation or transported, are subject to all requirements of Section 72.25(c)(6), 
Part 72, Title 42 CFR. 
II-C-4. Additional information on packaging and shipment is given 
in "Laboratory Safety Monograph - A supplement to the NIH Guidelines for 
Recomb inant DNA Research." 
Sincerely 
1 „ 
Chief, Standards Division 
Office of Hazardous Materials 
Regulation 
Materials Transportation Bureau 
[A-409] 
