UNIVERSITY OF CALIFORNIA SYSTEMWIDE ADMINISTRATION 
BERKELEY • DAVIS • IRVINE • LOS ANGELES • RIVERSIDE • SAN DIEGO • SAN FRANCISCO 
Office of the President 
SANTA BARBARA • SANTA CRUZ 
BERKELEY, CALIFORNIA 94720 
October 25, 1978 
Donald Fredrickson, M.D. 
Director 
National Institutes of Health 
Bethseda, Maryland 20014 
Dear Dr. Fredrickson: 
I want to pass on to you a statement prepared by my 
staff about the proposed revised guidelines on recombinant 
DNA research published in the Federal Register , July 28, 
1978. I fully endorse its conclusions concerning proposed 
changes, and I agree that principal responsibility for 
ensuring compliance should be borne by the institutions 
where the research is being done. 
Please be assured that the University, through its 
investigators, its institutional Biosafety Committees, and 
the Administration is prepared to carry out the expanded 
institutional responsibilities required by the proposed 
guidelines . 
Sincerely 
David S. Saxon 
President 
Attachment 
cc: Chancellors 
Executive Assistant David A. Wilson 
[A-440] 
