Dr. DonaldS. Fredrickson 
Page 2 
June 30, 1976 
If NIH should decide to contest the patent application with a view to 
reserving for itself the responsibility of determining the appropriate 
uses of recombinant DNA, this grant application (which should be 
available from GM) should provide legal evidence that the idea of 
genetic manipulation was in the common domain for several years 
prior to the actual experimental success. I have, moreover, dis- 
cussed the possibilities of genetic manipulation with students here 
at the University of Pittsburgh every year since 1970, adding further 
support to this idea. 
Garret M. Ihler, Ph. D. , M. D. 
Associate Professor of Biochemistry 
[ 63 ] 
