- 5 - 
DISCOVERY OF IMPORTANT NEW MEDICINES. It HAS NOT RESULTED IN ANY 
PUBLIC HEALTH PROBLEMS. 
One further example of industry's experience and capability is 
THE PRODUCTION OF MUTANT STRAINS OF BACTERIA AND OTHER MICROORGANISMS 
BY X-RAY AND OTHER MUTAGENIC TECHNIQUES IN RESEARCH DESIGNED 
TO INCREASE THE YIELD OF ANTIBIOTICS AND OTHER DRUG SUBSTANCES 
PRODUCED BY FERMENTATION. 
One MUST CONCLUDE from these examples AND from the excellent 
SAFETY RECORD OF THE INDUSTRY IN RESEARCH AND PRODUCTION OF OTHER 
POTENTIALLY BIOHAZARDOUS MATERIALS THAT IT IS WELL AWARE OF THE 
RISKS INVOLVED/ AND THAT IT HAS THE CAPABILITY TO AVOID CONTAMINATION 
OR INJURY TO ITS EMPLOYEES AND TO THE ENVIRONMENT. FOR PMA'S PART/ 
WE WILL EXERT EVERY EFFORT TO KEEP APPRISED OF OUR MEMBER FIRMS' 
INVOLVEMENT IN SUCH RESEARCH/ AND WILL ENCOURAGE COOPERATION WITH THE 
SCIENTIFIC COMMUNITY AND OTHER PEER GROUPS/ INCLUDING GOVERNMENT 
AGENCIES IN ADOPTING NECESSARY CONTROLS. 
IT IS TOO EARLY TO KNOW THE ULTIMATE OUTCOME OF MUCH OF THIS 
RESEARCH WHICH HAS AND WILL BE UNDERTAKEN. We MIGHT PREDICT/ HOWEVER/ 
THAT RECOMBINATION OF DMA IN A HOST BACTERIAL CELL COULD PRODUCE 
QUANTITIES OF MEDICALLY NEEDED NATURAL PRODUCTS SUCH AS HORMONES AND 
OTHER IMPORTANT DRUGS BY FERMENTATION PROCESSES RATHER THAT BY EXTRACTION 
OF SUCH RAW MATERIALS AS PANCREAS CR OTHER TISSUES OF ANIMALS AND PLANTS. 
Bacterial or other cultures of such recombinant DNA fragments 
COULD be MAINTAINED AND PROPAGATED TO SERVE AS A CONSTANT AND 
RELIABLE SOURCE FOR PRODUCTION. NEW RECOM3INANT MOLECULES MIGHT 
ALSO SERVE AS BASES FOR NEW ANTIBIOTICS OR AS A MEANS TO INCREASE 
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