- 2 - 
Dr. Fredrickson then discussed the functions and processes 
required in the regulation of recombinant DNA research (as envisioned 
under the NIH guidelines) which the agencies, both regulatory and 
performer, need to consider with regard to their respective roles: 
• registration of activity 
• certification of containment standards 
• oversight of investigators and institutions 
• formulation of an appellate mechanism to the above 
• requirements for safety education and training 
• development of safer hosts and vectors 
• establishment of a mechanism to provide hosts and vectors 
• exchange of information 
• establishment of international liaison 
• extension of the guidelines throughout the public 
and private sector 
• placement of ultimate authority 
Following this presentation, the NIH General Counsel briefly 
reviewed the potential regulatory authorities of the Center for Disease 
Control, the Food and Drug Administration, the Department of Transportation, 
the Environmental Protection Agency, the Department of Agriculture, and 
the Occupational Safety and Health Administration. 
The meeting was then open to the floor with ensuing discussions 
centering on the following topics: the application of recombinant DNA 
research standards to the private sector; the adoption of the NIH guide- 
lines by other Federal agencies, especially the Department of Agriculture; 
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