(c) Whether or not a strain of bacteria should be 
sought and studied to replace E. coli as the 
subject of most recombinant DNA experiments 
before this work be allowed to proceed. 
(d) Whether or not an "ordinary” or normal, non- 
hazardous gene from one organism might become 
dangerous if expressed in the wrong place and 
wrong time in the wrong organism (this important 
question was virtually ignored by the advisory 
committee) . 
A legislative-type hearing conducted by HEW is the best 
forum for full consideration of the issues raised by recombi- 
nant DMA research and technology. In effect, such a hearing 
would amount to a broad-based public review of the existing NIH 
guidelines and would permit open debate on 'issues given little 
or no attention by the NIH Drafting Committee or the office of 
the director. Whether the activity is transportation of 
recomb inant DNA materials, research, commercial production or 
use in the environment, HEW has the authority to regulate 
corporations and scientists whether oi not they receive federal 
research support. Therefore, it is highly appropriate for HEW 
to hold such a hearing. 
B. Final Regulations Governing All Parties Engaged 
Promulgation of the NIH guidelines reflects a consensus 
that recombinant DNA research and technology pose a sufficient 
hazard to the public health and the environment to require the 
prohibition of some experiments and the imposition of safety 
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